Adeno-associated virus (AAV) holds much promise as a vector for gene therapy. Although transgene expression usually occurs from extrachromosomal vector genomes, vectors occasionally integrate into the host genome. A new study in normal mammalian cells shows that the insertions are associated with genomic deletions and occur preferentially in actively transcribed genes.
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Russell, D. AAV loves an active genome. Nat Genet 34, 241–242 (2003). https://doi.org/10.1038/ng0703-241
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DOI: https://doi.org/10.1038/ng0703-241
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