Large-scale mutagenesis of the mouse genome is an essential task associated with the Human Genome Project. The two opposing schools of direct and reverse genetics have demonstrated comparable advantages, and yet large numbers of mutant lines have mostly been the prerogative of direct genetics. An improved gene-trapping resource now brings reverse genetics one step closer.
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Jackson, I. Mouse mutagenesis on target. Nat Genet 28, 198–200 (2001). https://doi.org/10.1038/90017
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DOI: https://doi.org/10.1038/90017
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