The spatial organization of the interphase nucleus is related to the differentiation state of the cell and has a role in establishing tissue-specific patterns of gene expression. Investigation of a tissue-specific nuclear protein has identified a new mechanism of cell-specific gene regulation that links nuclear architecture, chromatin structure and gene transcription.
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References
Brown, K.E. et al. Cell 91, 845–854 (1997).
Cremer, T. & Cremer, C. Nat. Rev. Genet. 2, 292–301 (2001).
Parada, L. & Misteli, T. Trends Cell Biol. 12, 425–432 (2002).
Volpi, E.V. et al. J. Cell Sci. 113 Pt 9, 1565–1576 (2000).
Mahy, N.L., Perry, P.E., Gilchrist, S., Baldock, R.A. & Bickmore, W.A. J. Cell Biol. 157, 579–589 (2002).
Hancock, R. Chromosoma 109, 219–225 (2000).
Forrester, W.C., Fernandez, L.A. & Grosschedl, R. Genes Dev. 13, 3003–3014 (1999).
Forrester, W.C., van Genderen, C., Jenuwein, T. & Grosschedl, R. Science 265, 1221–1225 (1994).
Jenuwein, T. et al. Nature 385, 269–272 (1997).
Bode, J. et al. Science 255, 195–197 (1992).
Kohwi-Shigematsu, T. & Kohwi, Y. Biochemistry 29, 9551–9560 (1990).
Dickinson, L.A., Joh, T., Kohwi, Y. & Kohwi-Shigematsu, T. Cell 70, 631–645 (1992).
Cai, S., Han, H.-J. & Kohwi-Shigematsu, T. Nat. Genet. 34, 42–51 (2003).
Wilsker, D., Patsialou, A., Dallas, P.B. & Moran, E. Cell Growth Differ. 13, 95–106 (2002).
Alvarez, J.D. et al. Genes Dev. 14, 521–535 (2000).
Yasui, D., Miyano, M., Cai, S., Varga-Weisz, P. & Kohwi-Shigematsu, T. Nature 419, 641–645 (2002).
Jenuwein, T. & Allis, C.D. Science 293, 1074–1080 (2001).
Berger, S.L. Curr. Opin. Genet. Dev. 12, 142–148 (2002).
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Shannon, M. A nuclear address with influence. Nat Genet 34, 4–6 (2003). https://doi.org/10.1038/ng0503-4
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DOI: https://doi.org/10.1038/ng0503-4
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