Cytokines regulate growth and functions of a variety of cells including immune and hematopoietic cells. The SOCS family proteins negatively regulate cytokine signaling, thereby preventing overactivation of cytokine-stimulated cells. A new study provides evidence that inactivation of SOCS-1, one of the SOCS family members, can be responsible for abnormal growth of hepatocellular carcinoma cells, suggesting that SOCS-1 may act as a tumor suppressor.
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Kishimoto, T., Kikutani, H. Knocking the SOCS off a tumor suppressor. Nat Genet 28, 4–5 (2001). https://doi.org/10.1038/ng0501-4
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DOI: https://doi.org/10.1038/ng0501-4
