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LEF1 turns over a new leaf

Nature Genetics volume 28, pages 3–4 (2001)Cite this article

LEF and TCF transcription factors (referred to collectively as LEF/TCFs) are pivotal players in the molecular pathology of cancer of the intestinal tract. Mutant components of the Wnt signal transduction cascade invariably lead to the inappropriate activation of LEF/TCFs in the cancer cell. A new study provides evidence for an unexpected amplification step in this cascade. The inappropriate activity of the Wnt pathway in colorectal cancer cells induces the expression of LEF1, which is normally not expressed in intestinal epithelium.

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Authors and Affiliations

  1. Department of Immunology and Center for Biomedical Genetics, University Medical Center, Utrecht, The Netherlands

    Wim de Lau & Hans Clevers

Authors
  1. Wim de Lau
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  2. Hans Clevers
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Lau, W., Clevers, H. LEF1 turns over a new leaf. Nat Genet 28, 3–4 (2001). https://doi.org/10.1038/ng0501-3

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