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A locus for bipolar affective disorder on chromosome 4p

Nature Genetics volume 12, pages 427–430 (1996)Cite this article

Abstract

The main clinical feature of bipolar affective disorder is a change of mood to depression or elation. Unipolar disorder, also termed majc depressive disorder, describes the occurrence c depression alone without episodes of elevate mood. Little is understood about the underlyim, causes of these common and severe illnesse which have estimated lifetime prevalences in th region of 0.8% for bipolar and 6% for unipola disorder1. Strong support for a genetic aetiolog is found in the familial nature of the condition, th increased concordance of monozygotic ove dizygotic twins2 and adoption studies showing increased rates of illness in children of affecte parents3. However, linkage studies have met wit mixed success. An initial report of linkage on th short arm of chromosome 11 (ref. 4) was revised5 and remains unreplicated. Reports proposirr cosegregation of genes found on the X chromosome with bipolar illness6 have not been supported by others7. More recently bipolar disorder ha been reported to be linked with markers on chromosomes 18, 21, 16 and a region on the X chromosome8–10 different from those previousl suggested11. We have carried out a linkage stud in twelve bipolar families. In a single family genome search employing 193 markers indicate linkage on chromosome 4p where the marke D4S394 generated a two-point lod score of 4. under a dominant model of inheritance. Thre point analyses with neighbouring markers gave maximum lod score of 4.8. Eleven other bipols families were typed using D4S394 and in all fam lies combined there was evidence of linkage wit heterogeneity with a maximum two-point lo score of 4.1 (θ = 0, α = 0.35).

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Authors and Affiliations

  1. Edinburgh University, Dept. of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh, EH10 5HF, UK

    Douglas H.R. Blackwood, Maura T. Walker, Kirstie Woodburn, Cliff M. Sharp, David M. St. Clair & Walter J. Muir

  2. MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, UK

    Douglas H.R. Blackwood, Lin He, Stewart W. Morris, Alan McLean, Claire Whitton, Marian Thomson, Allan F. Wright,, Yoshiro Shibasaki, David M. St. Clair, David J. Poreous & Walter J. Muir

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Blackwood, D., He, L., Morris, S. et al. A locus for bipolar affective disorder on chromosome 4p. Nat Genet 12, 427–430 (1996). https://doi.org/10.1038/ng0496-427

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