Mitochondrial signaling cascades have been implicated in the activation of programmed cell death and, more recently, control of cell proliferation. A nuclear gene encoding a mitochondrial Krebs-cycle protein, fumarate hydratase, is now shown to act as a major tumor-suppressor gene.
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BOB CRIMI
BOB CRIMI
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Rustin, P. Mitochondria, from cell death to proliferation. Nat Genet 30, 352–353 (2002). https://doi.org/10.1038/ng0402-352
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DOI: https://doi.org/10.1038/ng0402-352
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