A model for direct regulation of an entire genetic network by an organ-identity gene has been proposed. The relative affinities of the organ-identity transcription factor for different target sites control the timing of expression of downstream genes during development.
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Arnone, M. Bringing order to organogenesis. Nat Genet 30, 348–350 (2002). https://doi.org/10.1038/ng0402-348
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DOI: https://doi.org/10.1038/ng0402-348
