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Mutation of the MXI1 gene in prostate cancer

Nature Genetics volume 9, pages 249–255 (1995)Cite this article

Abstract

The Mxi1 protein negatively regulates Myc oncoprotein activity and thus potentially serves a tumour suppressor function. MXI1 maps to chromosome 10q24–q25, a region that is deleted in some cases of prostate cancer. We have detected mutations in the retained MXI1 alleles in four primary prostate tumours with 10q24–q25 deletions. Two tumours contained inactivating mutations, whereas two others contained the identical missense mutation. Fluorescence in situ hybridization also demonstrated loss of one MXI1 allele in an additional tumour lacking chromosome 10 abnormalities. MXI1 thus displays allelic loss and mutation in some cases of prostate cancer that may contribute to the pathogenesis or neoplastic evolution of this common malignancy.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, 15213, USA

    Linette R. Eagle, Xiaoying Yin & Edward V. Prochownik

  2. Departments of Pediatrics and Medical Genetics, The University of Utah Health Science Center, Salt Lake City, Utah, 84132, USA

    Arthur R. Brothman & Briana J. Williams

  3. Department of Cancer Research, Mount Vernon Hospital Northwood, Middlesex, HA6 2RN, UK

    N.B. Atkin

  4. The Department of Molecular Genetics and Biochemistry, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA

    Edward V. Prochownik

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Eagle, L., Yin, X., Brothman, A. et al. Mutation of the MXI1 gene in prostate cancer. Nat Genet 9, 249–255 (1995). https://doi.org/10.1038/ng0395-249

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