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Dense Alu clustering and a potential new member of the NFκB family within a 90 kilobase HLA Class III segment

Nature Genetics volume 3, pages 137–145 (1993)Cite this article

Abstract

We have conducted a detailed structural analysis of 90 kilobases (kb) of the HLA Class III region from the Bat2 gene at the centromeric end to 23 kb beyond TNF. A single contig of 80 kb was sequenced entirely with a group of four smaller contigs covering 10 kb being only partly sequenced. This region contains four known genes and a novel telomeric potential coding region. The genes are bracketed by long, dense clusters of Alu repeats belonging to all the major families. At least six new families of MER repeats and one pseudogene are intercalated within and between the Alu clusters. The most telomeric 3.8 kb contains three potential exons, one of which bears strong homology to the ankyrin domain of the DNA binding factors NFκB and IκB.

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Authors and Affiliations

  1. Centre d'Etude du Polymorphisme Humain, 27 Rue Juliette Dodu, 75010, Paris, France

    François J.M. Iris, Lydie Bougueleret, Sylvie Prieur, Dominique Caterina, Gwenaël Primas, Virginie Perrot, Patricia Rodriguez-Tome, Jean Dausset & Daniel Cohen

  2. Linus Pauling Institute of Science and Medicine, 440 Page Mill Road, Palo Alto, California, 94306, USA

    Jerzy Jurka

  3. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, 20894, USA

    Jean Michel Claverie

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Iris, F., Bougueleret, L., Prieur, S. et al. Dense Alu clustering and a potential new member of the NFκB family within a 90 kilobase HLA Class III segment. Nat Genet 3, 137–145 (1993). https://doi.org/10.1038/ng0293-137

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