Correction: Corrigendum: A transactivation-deficient mouse model provides insight into p53 regulation and function

Nat. Genet. 26, 37–43 (2000).

This article described the generation of a mouse in which homologous recombination was used to change codons 25 and 26 of the gene Trp53 to glutamine and serine. The initial sequencing of the full-length cDNA from mouse embryonic fibroblasts expressing this allele was considered to be wild-type at all codons except for 25 and 26. A reanalysis of the sequence showed that this mutant also contains a valine at codon 135, which is referred to as a “provisional wild type codon” in the National Center for Biotechnology Information's LocusLink tool (accession numbers: Trp53 mRNA, NM_011640; p53 protein, NP_035770). Sequence analysis showed that the lambda genomic clone containing an EcoRI fragment encompassing Trp53 (Nature 356, 215–221; 1992) that was used to prepare the targeting construct contained the Val135 codon, whereas Trp53 in laboratory mice (e.g., C57Bl6) encodes alanine at codon 135 (K. Krummel, F. Toledo, C. Lee & G.M.W., unpublished data). The properties of the two proteins have been investigated by M.N. et al. (Oncogene, in the press).