Abstract
WE are grateful to Gilardi1 for drawing attention to our use2 of the incorrect configuration of bicuculline. We have in fact, in more recent publications3, 4, used the correct configuration as determined by optical rotatory dispersion and circular dichroism measurements5. The energy calculations of the protonated bicuculline cation by Gilardi1 seem to be consistent with those made using other methods4, 6.
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References
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JOHNSTON, G., CURTIS, D. Configuration of Bicuculline, a GABA Antagonist |. Nature New Biology 246, 190 (1973). https://doi.org/10.1038/newbio246190a0
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DOI: https://doi.org/10.1038/newbio246190a0