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New Findings on Cephalosporin C Biosynthesis

Nature New Biology volume 246, pages 154–155 (1973)Cite this article

Abstract

IT has been reported that the fungus Cephalosporium sp. M8650 produces two peptide antibiotics, penicillin N and cephalosporin C, in the culture broth1–8. Three peptides which were presumed to be intermediates in the synthesis of β-lactam antibiotics have been isolated by Loder et al.9. Another group10 selected β-lactam antibiotic negative strains that accumulated sulphur-containing peptides. If any mutants that are defective in the biosynthesis of cephalosporin C are obtained, some of them would be expected to accumulate intermediates. This prompted us to obtain many cephalosporin C negative strains.

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Authors and Affiliations

  1. Microbiological Research Laboratories, Central Research Division, Takeda Chemical Industries, Juso, Osaka

    YUKIO FUJISAWA, HIDEO SHIRAFUJI, MAKOTO KIDA, KIYOSHI NARA, MASAHIKO YONEDA & TOSHIHIKO KANZAKI

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  1. YUKIO FUJISAWA
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  2. HIDEO SHIRAFUJI
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  3. MAKOTO KIDA
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FUJISAWA, Y., SHIRAFUJI, H., KIDA, M. et al. New Findings on Cephalosporin C Biosynthesis. Nature New Biology 246, 154–155 (1973). https://doi.org/10.1038/newbio246154a0

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