Abstract
FITZPATRICK et a.1 reported that serum from cystic fibrosis (CF) patients and heterozygotes had an increased capacity to bind Ca2+. These findings, if supported, could be important in the detection of the disease and carriers; however, Smith et al.2, using data from a larger sample of patients, failed to reproduce these findings. We therefore decided to reinvestigate the problem using both serum and plasma for the Ca2+ binding assay.
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References
Fitzpatrick, D. F., Landon, E., and James, V., Nature new Biol., 235, 173 (1972).
Smith, Q., Shapiro, B. L., Hamilton, M. J., and Warwick, W., Nature new Biol., 240, 56 (1972).
Fahey, J., and Terry, E., in Handbook of Experimental Immunology (edit, by Weir, D. M.), 19 (Blackwell, Oxford, 1967).
Schmoyer, I. R., Brooks, S., and Fischer, J., Life Sci., 11, 1037 (1972).
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DUFFY, M., COMER, D. & SCHWARZ, V. Serum Binding of Ca2+ and Cystic Fibrosis. Nature New Biology 246, 151 (1973). https://doi.org/10.1038/newbio246151a0
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DOI: https://doi.org/10.1038/newbio246151a0