Abstract
IT has generally been assumed that cyclic AMP, in common with other organic phosphates, crosses biological membranes only with difficulty. Cyclic nucleotides are, however, found in body fluids including plasma, gastric juice, CSF, milk and urine1; indeed cyclic nucleotides are the only organic phosphates that have been detected in urine2. There is evidence that some cells can release intracellular cyclic AMP; thus it is reported that glucagon, which stimulates cyclic AMP synthesis in the liver, causes a marked transient elevation of the concentration of the nucleotide in the blood3, 4.
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References
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FRANKLIN, T., FOSTER, S. Leakage of Cyclic AMP from Human Diploid Fibroblasts in Tissue Culture. Nature New Biology 246, 119–120 (1973). https://doi.org/10.1038/newbio246119a0
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DOI: https://doi.org/10.1038/newbio246119a0
