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Dopamine and 5-Hydroxytryptamine inhibit Feeding in Rats

Nature New Biology volume 246, pages 52–53 (1973)Cite this article

Abstract

Food satiated rats can be made to feed by intracerebral or intracerebroventricular injection of noradrenaline and other substances stimulating α-adrenoceptors1. Amphetamine and amphetamine derivatives such as fenfluramine are effective anorectic agents in rats and have been used to reduce food intake in man. The mechanisms by which they act have not been definitely demonstrated. Indirect evidence suggests that 5-hydroxytryptamine (5-HT) is involved in the anorectic action of fenfluramine2, and catecholamines in the anorectic activity of d-amphetamine in animals and in man3,4. The experiments described here were designed to investigate the neurotransmitters involved in mediating anorectic responses in rats.

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References

  1. Booth, D. A., J. Pharmac. exp. Ther., 160, 336 (1968).

    CAS  Google Scholar 

  2. Jespersen, S., and Scheel-Kruger, J., J. Pharm. Pharmac., 22, 637 (1970).

    Article  CAS  Google Scholar 

  3. Holtzmann, S. G., and Jewett, R. E., Psychopharmacologia, 22, 151 (1971).

    Article  Google Scholar 

  4. Calne, D. B., in Parkinsonism (Edward Arnold, London, 1970).

    Google Scholar 

  5. Bruce, R. B., and Maynard, W. R., J. Pharm. Sci., 57, 1173 (1968).

    Article  CAS  Google Scholar 

  6. Litchfield, J. T., and Wilcoxon, F., J. Pharmac. exp. Ther., 96, 99 (1949).

    CAS  Google Scholar 

  7. Anden, N. E., Butcher, S. G., Corrodi, H., Fuxe, H., and Ungerstedt, U., Europ. J. Pharmac., 11, 303 (1970).

    Article  CAS  Google Scholar 

  8. Stone, C. A., Wenger, H. C., Ludden, C. T., Stavorski, J. M., and Ross, C. A., J. Pharmac. exp. Ther., 131, 73 (1961).

    CAS  Google Scholar 

  9. Hayden, J. F., Johnson, L. R., and Maickel, R. P., Life Sci., 5, 1509 (1966).

    Article  CAS  Google Scholar 

  10. Mujik, M., and Van Rossum, J. M., Arch. int. Pharmacodyn. Ther., 185, 432 (1965).

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, The London Hospital Medical College, London, E1 2AD

    Z. L. KRUK

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  1. Z. L. KRUK
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KRUK, Z. Dopamine and 5-Hydroxytryptamine inhibit Feeding in Rats. Nature New Biology 246, 52–53 (1973). https://doi.org/10.1038/newbio246052a0

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