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Induction of Specific Helper Cells in vitro

Nature New Biology volume 245, pages 285–286 (1973)Cite this article

Abstract

ONE of the basic problems of immunology is the distinction between self and non-self1. The mechanism of self non-reactivity (self tolerance) is not yet known in detail, but since unimpaired self reactive B cells have been detected in several circumstances it now seems that self tolerance is essentially a property of T cells2–4. An understanding of the mechanism by which virgin T cells discriminate between immunity (to non-self) and tolerance (to self) is thus the key to understanding self tolerance.

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Author information

Author notes

  1. SIRKKA KONTIANEN

    Present address: Department of Serology and Bacteriology, University of Helsinki, Haartmaninkatu 3, 00290, Helsinki, 29

Authors and Affiliations

  1. Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, Gower Street, London, WC1

    SIRKKA KONTIANEN & MARC FELDMANN

Authors
  1. SIRKKA KONTIANEN
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  2. MARC FELDMANN
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Additional information

(reprints): Department of Serology and Bacteriology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki 29.

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KONTIANEN, S., FELDMANN, M. Induction of Specific Helper Cells in vitro. Nature New Biology 245, 285–286 (1973). https://doi.org/10.1038/newbio245285a0

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