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Studies on the Regeneration of Rhodopsin from All-Trans-Retinal in Isolated Rat Retinae

Nature New Biology volume 245, pages 221–223 (1973)Cite this article

Abstract

THERE is ample evidence to suggest that visual receptor rhodopsin consists of 11-cis-retinal linked through a Schiff base to the protein opsin1–4. When exposed to light, rhodopsin is converted to opsin and all-trans-retinal. The replenishment of rhodopsin in vivo requires an isomerisation system which converts all-trans-retinal to 11-cis retinal (see equation (3), scheme 1); the reaction of the latter with opsin to form rhodopsin is known to occur at a facile rate5.

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Authors and Affiliations

  1. Department of Physiology and Biochemistry, University of Southampton,

    S. AMER & M. AKHTAR

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  1. S. AMER
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  2. M. AKHTAR
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AMER, S., AKHTAR, M. Studies on the Regeneration of Rhodopsin from All-Trans-Retinal in Isolated Rat Retinae. Nature New Biology 245, 221–223 (1973). https://doi.org/10.1038/newbio245221a0

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