Abstract
CYTOPLASMIC factors which regulate genetic expression have been inferred to exist from the dramatic nucleo-cytoplasmic interactions observed in cell fusion1 and nuclear transplantation2 experiments. It has been proposed3 that such factors, which are necessarily gene products, also play a major role in differentiation processes. Nucleo-cytoplasmic feedback controls operate not only at the transcriptional level, but also at the post-transcriptional level, as suggested by kinetic data on the controlled nuclear processing and utilization of both ribosomal or messenger RNA4–6 and by DNA-RNA hybridization studies7,8, which indicate that much of the potential messenger RNA confined to the nucleus of the normal cell appears in the cytoplasm of the corresponding cancer cell.
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SCHUMM, D., McNAMARA, D. & WEBB, T. Cytoplasmic Proteins regulating Messenger RNA Release from Nuclei. Nature New Biology 245, 201–203 (1973). https://doi.org/10.1038/newbio245201a0
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DOI: https://doi.org/10.1038/newbio245201a0
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