Abstract
A GREAT deal of evidence shows that Ca2+ is critically involved in the release of acetylcholine (ACh) from motor nerve terminals1 and in the secretion of a variety of lipid-insoluble hormones and transmitters2. At the frog neuromuscular junction, Sr2+ and Ba2+ can replace Ca2+ (refs 3,4). When the motor nerve is stimulated tetanically in solutions without added Ca2+ or even in solutions containing Mg-EGTA there is an increase in miniature endplate potential (m.e.p.p.) frequency. The increase has been attributed to trace amounts of Ca2+ remaining in the solution outside the nerve terminals5, or to Mg2+ acting as a relatively ineffectual substitute for Ca2+ (ref. 6).
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References
Katz, B., The Release of Neural Transmitter Substances (Liverpool Univ. Press, Liverpool, 1969).
Rubin, R. P., Pharmacol. Rev., 22, 389 (1970).
Dodge, F. A., jun., Miledi, R., and Rahamimoff, R., J. Physiol., 200, 267 (1969).
Elmqvist, D., and Feldman, D. S., J. Physiol., 181, 487 (1965).
Miledi, R., and Thies, R., J. Physiol., 212, 245 (1971).
Hurlbut, W. P., Longenecker, H. B., jun., and Mauro, A., J. Physiol., 219, 17 (1971).
Mambrini, J., and Benoit, P. R., C.r. Séanc. Soc. Biol., 161, 524 (1967).
Dodge, F. A., jun., and Rahamimoff, R., J. Physiol., 193, 419 (1967).
Hubbard, J. I., Jones, S. F., and Landau, E. M., J. Physiol., 196, 75 (1968).
Kita, H., and Van der Kloot, W., Brain Res., 49, 205 (1973).
Cooke, J. D., Okamoto, K., and Quastel, D. M. J., J. Physiol., 228, 459 (1973).
Katz, B., and Miledi, R., J. Physiol., 207, 789 (1970).
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KITA, H., KLOOT, W. Action of Co and Ni at the Frog Neuromuscular Junction. Nature New Biology 245, 52–53 (1973). https://doi.org/10.1038/newbio245052a0
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DOI: https://doi.org/10.1038/newbio245052a0
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