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Amino Acid Acceptor Stem of E. coli Suppressor tRNATyr is a Site of Synthetase Recognition

Nature New Biology volume 244, pages 261–264 (1973)Cite this article

Abstract

Mutants of the su+m tyrosine suppressor tRNA gene specifying tRNAs with single base substitutions near the CCA terminus of the amino acid acceptor stem result in the ability to translate the UAG codon as glutamine. These mutant tRNAs are aminoacylated by the glutaminyl-tRNA synthetase. While some of the mutants also retain their ability to insert tyrosine at the UAG site, others can only insert glutamine.

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Author information

Author notes

  1. MARTIN L. HOOPER

    Present address: Centre de Génétique Moleculaire, 91 Gif-sur-Yvette, France

Authors and Affiliations

  1. Medical Research Council, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH

    JULIO E. CELIS, MARTIN L. HOOPER & JOHN D. SMITH

Authors
  1. JULIO E. CELIS
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  2. MARTIN L. HOOPER
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  3. JOHN D. SMITH
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CELIS, J., HOOPER, M. & SMITH, J. Amino Acid Acceptor Stem of E. coli Suppressor tRNATyr is a Site of Synthetase Recognition. Nature New Biology 244, 261–264 (1973). https://doi.org/10.1038/newbio244261a0

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  • DOI: https://doi.org/10.1038/newbio244261a0

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