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Molecular Conformations of Chondroitin-4-sulphate

Nature New Biology volume 244, pages 252–253 (1973)Cite this article

Abstract

CHONDROITIN-4-SULPHATE is a member of the connective tissue group of polysaccharides and occurs mainly in cartilage. The molecular chains are covalently linked to a protein core and act as a flexible connecting matrix between the tough protein filaments1–3. In common with many of the connective tissue polysaccharides, the isolated carbohydrate chains are based on a disaccharide repeat of the type (-A-B-)n, where A represents N-acetylgalactosamine-4-sulphate and B represents glucuronic acid. The glycosidic linkages and disposition of side groups are shown schematically in Fig. 1.

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Authors and Affiliations

  1. H. H. Wills Physics Laboratory, University of Bristol, Royal Fort, Tyndall Avenue, Bristol, BS8 1TL

    D. H. ISAAC & E. D. T. ATKINS

Authors
  1. D. H. ISAAC
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  2. E. D. T. ATKINS
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ISAAC, D., ATKINS, E. Molecular Conformations of Chondroitin-4-sulphate. Nature New Biology 244, 252–253 (1973). https://doi.org/10.1038/newbio244252a0

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