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Cholera Toxin inhibits Macromolecular Synthesis in Mouse Spleen Cells

Nature New Biology volume 244, pages 178–180 (1973)Cite this article

Abstract

UNDER appropriate experimental conditions, cholera enterotoxin affects a wide variety of non-intestinal tissues and cells1–3. As cholera toxin can profoundly alter normal cellular biochemical events, including lipolysis stimulation in fat cells, glycogenolysis in liver cells and platelets and the inhibition of histamine release from buffy coat cells from sensitized animals challenged with antigen4, we chose to study this material with the expectation that it might affect DNA synthesis and be useful for studying lymphocyte biochemistry.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, State University of New York, College of Medicine, Downstate Medical Center, Brooklyn, New York, 11203

    BARNET M. SULTZER & JOHN P. CRAIG

Authors
  1. BARNET M. SULTZER
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  2. JOHN P. CRAIG
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SULTZER, B., CRAIG, J. Cholera Toxin inhibits Macromolecular Synthesis in Mouse Spleen Cells. Nature New Biology 244, 178–180 (1973). https://doi.org/10.1038/newbio244178a0

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  • DOI: https://doi.org/10.1038/newbio244178a0

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