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A Wobbly Double Helix

Nature New Biology volume 244, pages 169–170 (1973)Cite this article

Abstract

CRICK1 first considered in the “wobble hypothesis” the biological relevance of base pairs beyond the canonical ones A:T(U) and G(I):C. Podder2 was able to estimate the stability of the G:U wobble pair from T jump relaxation spectra of the interacting tetranucleotides GpGpGpU:GpCpCpC. Paetkau et al.3 concluded from poly rG synthesis on d(T-C)n·d(G-A)n and d(T-C-C) by Escherichia coli RNA polymerase that under appropriate conditions thymine-guanine base pairing may occur during transcription.

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Authors and Affiliations

  1. Max-Planck-Institut für experimentelle Medizin, Abteilung Chemie, 34, Göttingen

    AXEL G. LEZIUS & ERIKA DOMIN

Authors
  1. AXEL G. LEZIUS
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  2. ERIKA DOMIN
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LEZIUS, A., DOMIN, E. A Wobbly Double Helix. Nature New Biology 244, 169–170 (1973). https://doi.org/10.1038/newbio244169a0

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