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Partial Characterization of RD114 Virus by DNA-RNA Hybridization Studies

Nature New Biology volume 244, pages 59–62 (1973)Cite this article

Abstract

TYPE C RNA tumour viruses (oncornaviruses) are widespread in vertebrate species including non-human primates1–4. By analogy it is assumed that human oncornaviruses exist and a recently isolated type C virus, RD114, seemed to be a candidate5. RD114 virus was produced by a human rhabdomyosarcoma cell line (RD114 cells), but only after these cells were passaged in the brain of a feline embryo6. The original cell line (RD) does not produce virus7. The RD114 virion differs in its chief internal polypeptides (group-specific antigen) and reverse transcriptase from all other known type C viruses, including feline leukaemia viruses8–12. Although the average base composition of the 70S RNA from RD114 virus differs from that of 70S RNA from Gardner-feline leukaemia virus (FeLV), it seems to be similar to that of 70S RNA from another strain of FeLV (strain 5)13,14.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, California, 90024

    M. A. BALUDA & P. ROY-BURMAN

  2. Departments of Pathology and Biochemistry, University of Southern California School of Medicine, Los Angeles, California, 90033

    M. A. BALUDA & P. ROY-BURMAN

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  1. M. A. BALUDA
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  2. P. ROY-BURMAN
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BALUDA, M., ROY-BURMAN, P. Partial Characterization of RD114 Virus by DNA-RNA Hybridization Studies. Nature New Biology 244, 59–62 (1973). https://doi.org/10.1038/newbio244059a0

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