Abstract
ANTIBODY complexed to target cells can induce killing of the target cell by certain non-immune lymphoid cells. Several studies (see refs 1–3 for recent reviews) have shown that antibody having this activity (“lymphocyte” dependent antibody or LDA) is of the IgG class and that the effector cells are thymus-independent cells4 bearing receptors for the Fc portion of IgG on their surface. Examples of this cytotoxic mechanism in vitro have now been described in xeno-, allo- and autoimmune situations1–3. More recent reports have implicated the mechanism in tumour rejection5–7 and LDA activity has been described in vitro against allogeneic myeloblasts8 and transplantation antigens in man9.
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HERSEY, P. New Look at Antiserum Therapy of Leukaemia. Nature New Biology 244, 22–24 (1973). https://doi.org/10.1038/newbio244022a0
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DOI: https://doi.org/10.1038/newbio244022a0
