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Propapain and its Conversion to Papain: A New Type of Zymogen Activation Mechanism involving Intramolecular Thiol-Disulphide Interchange

Nature New Biology volume 242, pages 167–170 (1973)Cite this article

Abstract

Propapain, a thiol-containing but catalytically inactive protein present in dried papaya latex, seems to be a structural isomer of papain that can be transformed to papain by intramolecular thiol-disulphide interchange.

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Authors and Affiliations

  1. Department of Biochemistry and Chemistry, St Bartholomew's Hospital Medical College, University of London, Charterhouse Square, London, EC1M 6BQ

    KEITH BROCKLEHURST & MAREK P. J. KIERSTAN

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  1. KEITH BROCKLEHURST
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  2. MAREK P. J. KIERSTAN
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BROCKLEHURST, K., KIERSTAN, M. Propapain and its Conversion to Papain: A New Type of Zymogen Activation Mechanism involving Intramolecular Thiol-Disulphide Interchange. Nature New Biology 242, 167–170 (1973). https://doi.org/10.1038/newbio242167a0

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  • DOI: https://doi.org/10.1038/newbio242167a0

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