Abstract
A NUMBER of hypotheses have been proposed to account for the well established fact that non-disjunction of chromosomes increases with advancing maternal age. Most are based on the assumption of mutational or cytoplasmic ageing in the prolonged dictyotene stage of the oocyte. Evans1 suggested that virus or other infections cause the nucleolus to persist in the oocyte, preventing the separation of half-bivalents at anaphase-I. Edwards2 found no evidence of nucleolar persistence in human oocytes, although he did not study this phenomenon in older animals.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Evans, H. J., Nature, 214, 361 (1967).
Edwards, R. G., Lancet, ii, 926 (1965).
Henderson, S. A., and Edwards, R. G., Nature, 218, 22 (1968).
German, J., Nature, 217, 516 (1968).
Rodman, T. C., Nature, 233, 191 (1971).
Yamamoto, M., and Ingalls, T. H., Science, 176, 518 (1972).
Goodlin, R. C., J. Reprod. Fertil., 9, 355 (1965).
Ingalls, T. H., and Yamamoto, M., Arch. Environ. Health, 24, 305 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
YAMAMOTO, M., ENDO, A. & WATANABE, G. Maternal Age Dependence of Chromosome Anomalies. Nature New Biology 241, 141–142 (1973). https://doi.org/10.1038/newbio241141a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio241141a0
This article is cited by
-
Sex ratio in mouse embryos in the postimplantation period of development
Bulletin of Experimental Biology and Medicine (1976)
-
Effects of Low-dose X-irradiation on Chromosomal Non-disjunction in Aged Mice
Nature (1974)
-
Effects of Low-dose X Irradiation on the Chromosomal Non-disjunction in Aged Mice
Nature New Biology (1973)