Abstract
SPONTANEOUSLY hypertensive rats (Okamoto-Aoki) (SHR) became normotensive following bilateral adrenalectomy1. In adrenalectomized SHR, hypertension was restored by the administration of adrenal cortical hormones2,3. Other reports confirmed that adrenal cortical hormones may play a principal role in the development and maintenance of hypertension4–9; increased catecholamine content10, tyrosine hydroxylase and dopamine-β-hydroxylase11 in adrenal medulla in the hypertension have also been demonstrated. The hypertension in rats was genetical and developed spontaneously. Blood pressures of all SHR rats increased, and systolic blood pressure was approximately 150 mm Hg at 8 weeks and approximately 200 mm Hg at 15 weeks old.
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AOKI, K., TAKIKAWA, K. & HOTTA, K. Role of Adrenal Cortex and Medulla in Hypertension. Nature New Biology 241, 122–123 (1973). https://doi.org/10.1038/newbio241122a0
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DOI: https://doi.org/10.1038/newbio241122a0
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