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Rabbit Memory Cells Are Not Restricted to the Affinity of Circulating Antibodies

Nature New Biology volume 241, pages 22–24 (1973)Cite this article

Abstract

DURING the primary immune response against certain antigenic determinants there is a progressive increase in the average intrinsic association constant of circulating antibodies1. Antibodies synthesized several weeks after antigen injection have higher affinity for the homologous ligand than those synthesized earlier2. According to clonal theories of antibody formation, the shift in the population of circulating molecules must reflect a shift in the population of high rate antibody-forming clones3–6.

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Authors and Affiliations

  1. Laboratory of Cell Biology, CNR, Via Romagnosi 18A, Rome

    ALBERTO J. L. MACARIO, EVERLY CONWAY DE MACARIO & FRANCO CELADA

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  1. ALBERTO J. L. MACARIO
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  2. EVERLY CONWAY DE MACARIO
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  3. FRANCO CELADA
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MACARIO, A., DE MACARIO, E. & CELADA, F. Rabbit Memory Cells Are Not Restricted to the Affinity of Circulating Antibodies. Nature New Biology 241, 22–24 (1973). https://doi.org/10.1038/newbio241022b0

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