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Human Growth Hormone Radioreceptor Assay using Cultured Human Lymphocytes

Nature New Biology volume 241, pages 20–22 (1973)Cite this article

Abstract

RADIOMMUNOASSAY has been widely applied to the measurement of circulating growth hormone. Although sensitive and precise methods for measuring immunoreactive growth hormone in plasma are available, there have been no methods for quantitatively measuring the biological activity of growth hormone. Hormone receptor interactions have been studied extensively (refs. 1 and 2 and further refs. in ref. 1) and precise sensitive methods have been developed for measuring the concentration of polypeptide hormones based on their interaction with a biological tissue3,4. These biological methods not only have the precision and frequently the sensitivity of the radioimmunoassay but in addition they have biological specificity.

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Authors and Affiliations

  1. Clinical Endocrinology Branch, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland, 20014

    MAXINE A. LESNIAK, JESSE ROTH, PHILLIP GORDEN & JAMES R. GAVIN III

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  1. MAXINE A. LESNIAK
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  2. JESSE ROTH
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  3. PHILLIP GORDEN
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  4. JAMES R. GAVIN III
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LESNIAK, M., ROTH, J., GORDEN, P. et al. Human Growth Hormone Radioreceptor Assay using Cultured Human Lymphocytes. Nature New Biology 241, 20–22 (1973). https://doi.org/10.1038/newbio241020a0

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