Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Two New Linkage Groups in Man, both carrying Different Loci for Lactate Dehydrogenase and Glutamic-Pyruvic Transaminase

Nature New Biology volume 240, pages 221–223 (1972)Cite this article

Abstract

MAN-Chinese hamster somatic cell hybrids can be used in the genetic analysis of man1–4, because human chromosomes are lost in proliferating man-Chinese hamster somatic cell hybrids and consequently clonal lines with different numbers and combinations of human chromosomes can be obtained. Because many homologous enzymes of man and Chinese hamster can be distinguished by electrophoretic techniques, a large number of gene markers is available.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Westerveld, A., Meera Khan, P., Visser, R. P. L. S., and Bootsma, D., Nature New Biology, 234, 20 (1971).

    Article  CAS  Google Scholar 

  2. Meera Khan, P., Arch. Biochem. Biophys., 145, 470 (1971).

    Article  CAS  Google Scholar 

  3. Westerveld, A., and Meera Khan, P., Nature, 236, 30 (1972).

    Article  CAS  Google Scholar 

  4. Meera Khan, P., Westerveld, A., Grzeschik, K. H., Deys, B. F., Garson, O. M., and Siniscalco, M., Amer. J. Hum. Genet., 23, 614 (1971).

    CAS  PubMed  Google Scholar 

  5. Chen, S.-H., and Giblett, E. R., Science, 173, 148 (1971).

    Article  CAS  Google Scholar 

  6. Meera Khan, P., and van Someren, H., Science (in the press).

  7. Ruddle, F. H., Chapman, V. M., Chen, T. R., and Klebe, R. J., Nature, 227, 251 (1970).

    Article  CAS  Google Scholar 

  8. Santachiari, A. S., Nabholz, M., Miggiano, V., Darlington, A. J., and Bodmer, W., Nature, 227, 248 (1970).

    Article  Google Scholar 

  9. Grzeschik, K. H., Romeo, G., Grzeschik, A. M., Banhof, S., Siniscalco, M., van Someren, H., Meera Khan, P., Westerveld, A., and Bootsma, D., Nature (in the press).

  10. van Someren, H., and Meera Khan, P., Arch. Biochem. Biophys. (in the press).

  11. Ohno, S., Evolution by Gene Duplication (Springer Verlag, Berlin, Heidelberg, New York, 1970).

    Book  Google Scholar 

  12. Ruddle, F. H., Adv. Hum. Genet., 4, 173 (1972).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Molecular Genetics, Leiden State University, Leiden

    H. VAN SOMEREN

  2. Department of Human Genetics, Leiden State University, Leiden

    P. MEERA KHAN

  3. Medical Biological Laboratory TNO, Leiden

    A. WESTERVELD

  4. Department of Cell Biology and Genetics, Medical Faculty, Rotterdam

    D. BOOTSMA

Authors
  1. H. VAN SOMEREN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. MEERA KHAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. WESTERVELD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. BOOTSMA
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

VAN SOMEREN, H., KHAN, P., WESTERVELD, A. et al. Two New Linkage Groups in Man, both carrying Different Loci for Lactate Dehydrogenase and Glutamic-Pyruvic Transaminase. Nature New Biology 240, 221–223 (1972). https://doi.org/10.1038/newbio240221a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio240221a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing