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Molecular Basis of Gouty Inflammation: Interaction of Monosodium Urate Crystals with Lysosomes and Liposomes

Nature New Biology volume 240, pages 167–172 (1972)Cite this article

Abstract

Crystals of monosodium urate, like silica, rupture lysosomes and liposomes in media which do not constrain hydrogen bonding. Liposomes are rendered susceptible to urate-induced lysis if they contain cholesterol and testosterone, but refractory if they contain 17-β-oestradiol. Similar events in vivo may account for crystal-induced gouty inflammation as well as explain why men rather than women get acute gout.

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Author notes

  1. GIUSEPPE A. RITA

    Present address: Institute of General Pathology, University of Turin, Turin, Italy

Authors and Affiliations

  1. Department of Medicine (Cell Biology), New York University School of Medicine,

    GERALD WEISSMANN & GIUSEPPE A. RITA

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  1. GERALD WEISSMANN
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  2. GIUSEPPE A. RITA
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WEISSMANN, G., RITA, G. Molecular Basis of Gouty Inflammation: Interaction of Monosodium Urate Crystals with Lysosomes and Liposomes. Nature New Biology 240, 167–172 (1972). https://doi.org/10.1038/newbio240167a0

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  • DOI: https://doi.org/10.1038/newbio240167a0

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