Abstract
GENE duplication was first observed cytologically in the bar gene of drosophila1. The idea, extended by Dixon2, has been used to explain the obvious repeats in amino-acid sequence in the immunoglobulins, in bacterial ferredoxins, in haptoglobin α-2 (summarized in ref. 3) and in neurophysin4.
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References
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KRETSINGER, R. Gene Triplication deduced from the Tertiary Structure of a Muscle Calcium Binding Protein. Nature New Biology 240, 85–88 (1972). https://doi.org/10.1038/newbio240085a0
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DOI: https://doi.org/10.1038/newbio240085a0
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