Abstract
SINCE 6-hydroxydopamine does not cross the blood-brain barrier in adult animals1, it has to be given by intracerebral injection to produce specific degeneration of catecholamine-containing nerve endings in the central nervous system2,3. The resulting permanent depletion of noradrenaline and dopamine in all regions of the brain makes it difficult to determine the neuronal tracts and brain regions involved in a physiological or behavioural disfunction after 6-hydroxydopamine treatment4. Localization of nerve destruction can be improved by direct intracerebral injection of 6-hydroxydopamine at specific neuronal sites5 by pretreatment with drugs that affect catecholamine uptake6 or by varying the dosage of 6-hydroxydopamine7. These procedures are, however, technically difficult.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Laverty, R., Sharman, D. F., & Vogt, M., Brit. J. Pharmacol., 24, 759 (1965).
Bloom, F. E., Algeri, S., Groppetti, A., Revueita, A., & Costa, E., Science, 166, 1284 (1969).
Uretsky, N. J., & Iversen, L. L., Nature, 221, 557 (1969).
Laverty, R., & Taylor, K. M., Brit. J. Pharmacol., 40, 836 (1970).
Ungerstedt, U., in 6-Hydroxydopamine and Catecholamine Neurones (edit. by Malmfors, T., and Thoenen, H.), 315 (North Holland, Amsterdam, 1971).
Taylor, K. M., & Laverty, R., Europ. J. Pharmacol., 17, 16 (1972).
Uretsky, N. J., & Iversen, L. L., J. Neurochem., 17, 269 (1970).
Clark, D. W. J., Laverty, R., & Phelan, E. L., Brit. J. Pharmacol. 44, 233 (1972).
Smart, J. L., & Dobbing, J., Brain Res., 28, 85 (1971).
Coyle, J. T., & Axelrod, J., J. Neurochem., 18, 2061 (1971).
Dobbing, J., in Prog, in Brain Res. (edit. by Lajtha, A., and Ford, D.), 29, 417 (Elsevier, Amsterdam, 1968).
Dahlstrom, A., & Fuxe, K., Acta Physiol. Scand., 62, Suppl. 232, 1 (1964).
Schildkraut, J. J., Amer. J. Psychiat., 122, 509 (1965).
Steinberg, H., Rushton, R., & Tinson, C., Nature, 192, 533 (1961).
Cook, L., & Weidley, E., Ann. NY Acad. Sci., 66, 740 (1957).
Fastier, F. N., Speden, R. N., & Waal, J., Brit. J. Pharmacol., 12, 251 (1957).
Laverty, R., & Taylor, K. M., Anal. Biochem., 22, 269 (1968).
Ashcroft, G. W., & Sharman, D. F., Brit. J. Pharmacol., 19, 153 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TAYLOR, K., CLARK, D., LAVERTY, R. et al. Specific Noradrenergic Neurones destroyed by 6-Hydroxydopamine Injection into Newborn Rats. Nature New Biology 239, 247–248 (1972). https://doi.org/10.1038/newbio239247a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/newbio239247a0
This article is cited by
-
Attenuation of heroin reward in rats by disruption of the mesolimbic dopamine system
Psychopharmacology (1983)
-
Clonidine-induced sedation in rats: Evidence for mediation by postsynaptic? 2-adrenoreceptors
Journal of Neural Transmission (1982)
-
Alcohol intake, ethanol-induced narcosis and intoxication in rats following neonatal 6-hydroxydopamine or 5,7-dihydroxytryptamine treatment
Naunyn-Schmiedeberg's Archives of Pharmacology (1979)
-
Operant behavioural and neurochemical effects after neonatal 6-hydroxydopamine treatment
Psychopharmacology (1976)
-
Effects of 6-hydroxydopamine treatment at birth on the submaxillary gland of the rat
Naunyn-Schmiedeberg's Archives of Pharmacology (1975)
