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Inhibition of Adenosine Uptake by Platelets

Abstract

ADENOSINE inhibits platelet aggregation induced by adenosine diphosphate both in vivo and in vitro1,2. In platelet-rich plasma, inhibition by adenosine first increases and then decreases1–6, presumably because adenosine is either incorporated into the platelet and converted to nucleotides, or degraded in the plasma by adenosine deaminase (ADA) to inosine and then hypoxanthine6,7.

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JENKINS, C., CAEN, J., VAINER, H. et al. Inhibition of Adenosine Uptake by Platelets. Nature New Biology 239, 210–211 (1972). https://doi.org/10.1038/newbio239210a0

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