Abstract
TETRODOTOXIN (TTX), the powerful neurotoxin of the puffer fish, blocks electrical excitation of many neuronal and muscle membranes1. This neurotoxin selectively blocks the sodium conductance increase, leaving the delayed potassium conductance change unaltered2–6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kao, C. Y., Pharmac. Rev., 18, 997 (1966).
Narahashi, T., Deguchi, T., Urakawa, N., & Ohkubo, Y., Amer. J. Physiol., 198, 934 (1960).
Nakajima, S., Iwasaki, S., & Obata, K., J. Gen. Physiol., 46, 97 (1962).
Narahashi, T., Moore, J. W., & Scott, W. R., J. Gen. Physiol., 47, 965 (1964).
Nakamura, Y., Nakajima, S., & Grundfest, H., J. Gen. Physiol., 48, 985 (1965).
Takata, M., Moore, J. W., Kao, C. Y., & Fuhrman, F. A., J. Gen. Physiol., 49, 967 (1966).
McIlwain, H., Harvey, J. A., & Rodriguez, G., J. Neurochem., 16, 363 (1969).
Okamoto, K., & Quastel, J. H., Biochem. J., 120, 37 (1970).
Bernardi, G., Zieglgänsberger, W., Herz, A., & Puil, E. A., Brain Res., 39, 523 (1972).
Blankenship, J. E., J. Neurophysiol., 31, 186 (1968).
Phillis, J. W., Tebecis, A. K., & York, D. H., Nature, 217, 271 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ZIEGLGÄNSBERGER, W., PUIL, E. Tetrodotoxin Interference of CNS Excitation by Glutamic Acid. Nature New Biology 239, 204–205 (1972). https://doi.org/10.1038/newbio239204a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio239204a0
This article is cited by
-
Ionic mechanisms associated with the depolarization by glutamate and aspartate on human and rat spinal neurones in tissue culture
Pfl�gers Archiv European Journal of Physiology (1976)
-
Animal neurotoxins in neurobiological research
Experientia (1974)