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E-type Prostaglandins and Gastric Acid Secretion in the Rat

Nature New Biology volume 238, pages 177–179 (1972)Cite this article

Abstract

IT is known that prostaglandins of the ? series (PGEs) inhibit gastric acid secretion1–4, but the relative potencies of prostaglandin E1 and prostaglandin E2 have not been evaluated. We report observations which indicate that orally administered PGE2 has a considerably longer duration of action than an equipotent oral dose of PGE1 in inhibiting pentagastrin-induced gastric acid secretion in the rat and that this inhibitory action appears to be due to a local action on the gastro-intestinal wall rather than to absorption of prostaglandins into the systemic circulation.

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Authors and Affiliations

  1. Pharmacological Research Laboratories, May and Baker Ltd, Dagenham, Essex

    A. K. BANERJEE, JEAN PHILLIPS & W. M. WINNING

Authors
  1. A. K. BANERJEE
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  2. JEAN PHILLIPS
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  3. W. M. WINNING
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BANERJEE, A., PHILLIPS, J. & WINNING, W. E-type Prostaglandins and Gastric Acid Secretion in the Rat. Nature New Biology 238, 177–179 (1972). https://doi.org/10.1038/newbio238177a0

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  • DOI: https://doi.org/10.1038/newbio238177a0

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