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Effects of α-Amanitin in vivo on RNA Polymerase and Nuclear RNA Synthesis

Nature New Biology volume 238, pages 161–164 (1972)Cite this article

Abstract

The fungal toxin α-amanitin given in vivo selectively inhibits for 10–60 min a nucleoplasmic type of RNA polymerase in rat liver but the synthesis in vivo of all species of nuclear RNA remains blocked for several hours.

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Author notes

  1. J. R. TATA & D. SHIELDS

    Present address: National Institute for Medical Research, Mill Hill, London, NW7 1AA, England

  2. MARY JO HAMILTON

    Present address: Department of Biological Sciences, University of Idaho, Moscow, Idaho, USA

Authors and Affiliations

  1. Department of Biochemistry, University of California, Berkeley

    J. R. TATA, MARY JO HAMILTON & D. SHIELDS

  2. National Institute for Medical Research, Mill Hill, London, NW7 1AA

    J. R. TATA, MARY JO HAMILTON & D. SHIELDS

Authors
  1. J. R. TATA
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  2. MARY JO HAMILTON
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  3. D. SHIELDS
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TATA, J., HAMILTON, M. & SHIELDS, D. Effects of α-Amanitin in vivo on RNA Polymerase and Nuclear RNA Synthesis. Nature New Biology 238, 161–164 (1972). https://doi.org/10.1038/newbio238161a0

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  • DOI: https://doi.org/10.1038/newbio238161a0

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