Abstract
VARIOUS types of cells release an inducer for the formation of colonies in vitro with mature differentiated macrophages and granulocytes from single normal undifferentiated haematopoietic cells1–8. Using purified inducer from a cloned line of mouse fibroblasts, we have shown that this induction requires a protein (MGI) with a molecular weight of 65–70,000 and a low molecular weight co-factor, both secreted by the fibroblasts9. Adenine or adenine-containing nucleotides can substitute for the co-factor9,10. We have also shown that non-purified conditioned medium produced by human cells can induce undifferentiated cells from patients with acute myeloid leukaemia to differentiate into mature granulocytes11.
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References
Pluznik, D. H., and Sachs, L., J. Cell. Comp. Physiol., 66, 319 (1965).
Pluznik, D. H., and Sachs, L., Exp. Cell Res., 43, 553 (1966).
Ichikawa, Y., Pluznik, D. H., and Sachs, L., Proc. US Nat. Acad. Sci., 56, 488 (1966).
Ichikawa, Y., Pluznik, D. H., and Sachs, L., Proc. US Nat. Acad. Sci., 58, 1480 (1967).
Paran, ML., and Sachs, L., J. Cell. Physiol., 72, 247 (1968).
Paran, M., and Sachs, L., J. Cell. Physiol., 73, 91 (1969).
Sachs, L., in Regulation of Hematopoiesis, 217 (Appleton-Century-Crofts, New York, 1970).
Metcalf, D., and Bradley, T. R., in Regulation of Hematopoiesis, 187 (Appleton-Century-Crofts, New York, 1970).
Landau, T., and Sachs, L., Proc US Nat. Acad. Sci., 68, 2540 (1971).
Landau, T., and Sachs, L., FEBS Letters, 17, 339 (1971).
Paran, M., Sachs, L., Barak, Y., and Resnitzky, P., Proc. US Nat. Acad. Sci., 67, 1542 (1970).
Ichikawa, Y., J. Cell. Physiol., 74, 223 (1969).
Metcalf, D., Moore, A. S., and Warner, N. L., J. Nat. Cancer Inst., 43, 983 (1969).
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FIBACH, E., LANDAU, T. & SACHS, L. Normal Differentiation of Myeloid Leukaemic Cells induced by a Differentiation-inducing Protein. Nature New Biology 237, 276–278 (1972). https://doi.org/10.1038/newbio237276a0
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DOI: https://doi.org/10.1038/newbio237276a0
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