Abstract
THE greater biological potency of salmon calcitonin (SCT) as compared with mammalian calcitonins may be due to the relative resistance of SCT to inactivation in vivo1,2. SCT infused into dogs disappears from the circulation more slowly than does porcine calcitonin (PCT) or human calcitonin (HCT)1–3. For example, the metabolic clearance rate (MCR) of PCT in the dog is approximately 10 times greater than that of SCT1,2. Neither renal excretion3,4 nor inactivation by plasma1,2 is sufficient to account for the rapid clearance of the calcitonins that we have observed in vivo, and thus it seemed likely that inactivation of the hormones must occur during passage through one or more organs. Here we present data that suggest the kidney, the liver, and muscle and/or bone as the sites of inactivation of the calcitonins in the dog. SCT is relatively resistant to inactivation in the latter two sites.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Habener, J. F., Singer, F. R., Deftos, L. J., Neer, R. M., and Potts, jun., J. T., Nature New Biology, 232, 91 (1971).
Habener, J. F., Singer, F. R., Neer, R. M., Deftos, L. J., and Potts, jun., J. T., Proceedings of the Fourth Parathyroid Conference (edit. by Talmage, R. V.), Excerpta Medica, Amsterdam (in the press).
Foster, G. V., Clark, M. B., Williams, C., Nathanson, B. M., Horton, R., Buranapong, P., and Glass, H. L., Endocrinology 1971, Proceedings of the Third International Symposium (edit. by Taylor, S.) (William Heinemann, London, in the press).
Neer, R. M., Parsons, J. A., Krane, S. M., Deftos, L. J., Shields, C. L., and Potts, jun., J. T., Calcitonin 1969, Proceedings of the Second International Symposium (edit. by Taylor, S., and Foster, G.), 547 (William Heinemann, London, 1970).
West, T. E. T., Jaffee, M., Sinclair, L., and O'Riordan, J. L. H., Lancet, i, 675 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SINGER, F., HABENER, J., GREENE, E. et al. Inactivation of Calcitonin by Specific Organs. Nature New Biology 237, 269–270 (1972). https://doi.org/10.1038/newbio237269a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio237269a0
