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Early Increase in Nuclear Acidic Protein Synthesis after SV40 Infection

Nature New Biology volume 237, pages 240–241 (1972)Cite this article

Abstract

WHEN the replication of density-inhibited cultures of fibroblasts1,2 is stimulated by a change of medium3–5, the rate of nuclear acidic protein synthesis10–13 is immediately increased. We wanted to determine whether the induction of cellular DNA synthesis by an oncogenic virus6–9 is also preceded by nuclear acidic protein synthesis. We report here the effect of SV40 virus infection of a permissive and a non-permissive cell line on their synthesis of total cellular proteins and nuclear acidic proteins in the first hours after infection.

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References

  1. Golde, A., Virology, 16, 9 (1963).

    Article  Google Scholar 

  2. Levine, E. M., Becker, Y., Boone, C. W., and Eagle, H., Proc. US Nat. Acad. Sci., 53, 350 (1965).

    Article  CAS  Google Scholar 

  3. Todaro, G. J., Lazar, G. K., and Green, H., J. Cell. Comp. Physiol., 66, 325 (1965).

    Article  CAS  Google Scholar 

  4. Yoshikura, H., Hirokawa, Y., and Yamada, M., Exp. Cell Res., 48, 226 (1967).

    Article  CAS  Google Scholar 

  5. Becker, Y., and Levitt, J., Exp. Cell Res., 51, 27 (1968).

    Article  CAS  Google Scholar 

  6. Gershon, D., Sachs, L., and Winocour, E., Proc. US Nat. Acad. Sci., 56, 918 (1966).

    Article  CAS  Google Scholar 

  7. Hatanaka, M., and Dulbecco, R., Proc. US Nat. Acad. Sci., 56, 736 (1966).

    Article  CAS  Google Scholar 

  8. Henry, P. P., Black, H., Oxman, M. N., and Weissman, S. M., Proc. US Nat. Acad. Sci., 56, 1170 (1965).

    Article  Google Scholar 

  9. Sauer, G., and Defendi, V., Proc. US Nat. Acad. Sci., 56, 452 (1966).

    Article  CAS  Google Scholar 

  10. Farber, J., Rovera, G., and Baserga, R., Biochem. J., 122, 189 (1971).

    Article  CAS  Google Scholar 

  11. Rovera, G., Farber, J., and Baserga, R., Proc. US Nat. Acad. Sci., 68, 1725 (1971).

    Article  CAS  Google Scholar 

  12. Rovera, G., and Baserga, R., J. Cell. Physiol., 77, 201 (1971).

    Article  CAS  Google Scholar 

  13. Baserga, R., and Stein, G., Fed. Proc. (in the press).

  14. Lehman, J. M., and Defendi, V., J. Virology, 6, 738 (1970).

    CAS  PubMed  Google Scholar 

  15. Jensen, F., Girardi, A. J., Gilden, R. V., and Koprowski, H., Proc. US Nat. Acad. Sci., 52, 53 (1964).

    Article  CAS  Google Scholar 

  16. Baserga, R., Rovera, G., and Farber, J., In Vitro, 2, 80 (1971).

    Article  Google Scholar 

  17. Kaplan, A. S., and Ben Porat, T., Ann. Rev. Microbiol., 22, 427 (1968).

    Article  CAS  Google Scholar 

  18. Winocour, E., and Rollins, E., Virology, 40, 307 (1970).

    Article  CAS  Google Scholar 

  19. Barbanti-Brodano, G., Swetly, P., and Koprowski, H., J. Virology, 6, 78 (1970).

    CAS  PubMed  Google Scholar 

  20. Hummeler, K., Tomassini, M., and Sokol, F., J. Virology, 6, 87 (1970).

    CAS  PubMed  Google Scholar 

  21. Patterson, M. S., and Green, R. C., Anal. Chem., 37, 854 (1965).

    Article  CAS  Google Scholar 

  22. Burton, K., Biochem. J., 62, 315 (1956).

    Article  CAS  Google Scholar 

  23. Lowry, O. H., Rosebrough, N. J., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology, Temple University School of Medicine, Philadelphia, Pennsylvania

    GIOVANNI ROVERA & RENATO BASERGA

  2. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania

    VITTORIO DEFENDI

Authors
  1. GIOVANNI ROVERA
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  2. RENATO BASERGA
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  3. VITTORIO DEFENDI
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ROVERA, G., BASERGA, R. & DEFENDI, V. Early Increase in Nuclear Acidic Protein Synthesis after SV40 Infection. Nature New Biology 237, 240–241 (1972). https://doi.org/10.1038/newbio237240a0

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