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Normal Function of Transplanted Mouse Erythrocyte Precursors for 21 Months beyond Donor Life Spans

Nature New Biology volume 237, pages 220–222 (1972)Cite this article

Abstract

AGEING may be a programmed event which occurs in all the tissues of an animal at about the same rate, the rate determining the species life span1. This programmed ageing theory is supported by observed limitations on numbers of cell doublings of human fibroblasts1 or on proliferative capacity of mouse mammary gland2 and mouse marrow3,4, but recent studies show that the proliferative capacity of mouse marrow is not constant, but is greatly increased by lengthening the time intervals between transplants5. Direct measurement of functional capacity is therefore a more valuable test of senescence than is proliferative capacity.

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Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, Maine, 04609

    D. E. HARRISON

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  1. D. E. HARRISON
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HARRISON, D. Normal Function of Transplanted Mouse Erythrocyte Precursors for 21 Months beyond Donor Life Spans. Nature New Biology 237, 220–222 (1972). https://doi.org/10.1038/newbio237220a0

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