Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Formation of a Hybrid Enzyme between Echinoderm Arginine Kinase and Mammalian Creatine Kinase

Nature New Biology volume 237, pages 51–53 (1972)Cite this article

Abstract

MOST intracellular enzymes are composed of more than one subunit. Where this is so, specificity in the interaction between subunits must be as important as specificity for substrates and the integrity of the catalytic structures of the molecule. All these features of enzyme proteins arise from their specific primary structures and may be modified during evolution as a result of changes in amino-acid sequence. The problem is posed as to whether the chemical structures within a subunit enabling it to combine with others are conserved during evolution or, on the other hand, whether they are modified during the divergence of homologous enzymes and isoenzymes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Watts, D. C., in Molecular Evolution (edit. by Schoffeniels, E.), 2, 150 (North-Holland, Amsterdam, 1971).

    Google Scholar 

  2. der Terrossian, E., Desvages, G., Pradel, L. A., Kassab, R., and van Thoai, N., Europ. J. Biochem., 22, 585 (1971).

    Article  CAS  Google Scholar 

  3. Burger, A., Eppenberger, M. E., Weissman, U., and Richterich, R., Heb. Physiol. Acta, 21, C6 (1963).

    CAS  Google Scholar 

  4. Dawson, D. M., Eppenberger, H. M., and Kaplan, N. O., Blochem. Biophys. Res. Commun., 21, 346 (1965).

    Article  CAS  Google Scholar 

  5. Eppenberger, H. M., Eppenberger, M. E., Richterich, R., and Aebi, H., Develop. Biol., 10, 1 (1964).

    Article  CAS  Google Scholar 

  6. Eppenberger, M. E., Eppenberger, H. M., and Kaplan, N. O., Nature, 214, 239 (1967).

    Article  CAS  Google Scholar 

  7. Moreland, B., Watts, D. C., and Virden, R., Nature, 214, 458 (1967).

    Article  CAS  Google Scholar 

  8. Lacombe, G., van Thiem, N., and van Thoai, N., Europ. J. Biochem., 9, 237 (1969).

    Article  CAS  Google Scholar 

  9. Focant, B., FEBS Lett., 10, 57 (1970).

    Article  CAS  Google Scholar 

  10. Virden, R., and Watts, D. C., Comp. Biochem. Physiol., 13, 161 (1964).

    Article  CAS  Google Scholar 

  11. Blethen, S. L., and Kaplan, N. O., Biochemistry, 7, 2123 (1968).

    Article  CAS  Google Scholar 

  12. Eppenberger, H. M., in Homologous Enzymes and Biochemical Evolution (edit. by van Thoai, N., and Roche, J.), 231 (Gordon and Breach, New York, London, Paris, 1968).

    Google Scholar 

Download references

Author information

Author notes

  1. B. FOCANT

    Present address: Institut E. Van Beneden, Laboratoire de Biologie Generale, 22 quai Van Beneden, B-4000, Liège, Belgium

Authors and Affiliations

  1. Biochemistry Department, Guy's Hospital Medical School, London, SE1 9RT

    D. C. WATTS, B. FOCANT, B. M. MORELAND & R. L. WATTS

Authors
  1. D. C. WATTS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. FOCANT
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. M. MORELAND
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. L. WATTS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WATTS, D., FOCANT, B., MORELAND, B. et al. Formation of a Hybrid Enzyme between Echinoderm Arginine Kinase and Mammalian Creatine Kinase. Nature New Biology 237, 51–53 (1972). https://doi.org/10.1038/newbio237051a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio237051a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing