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Cytotoxic Activity in vitro of Thymus-derived Lymphocytes Sensitized to Xenograft Antigens

Nature New Biology volume 237, pages 17–18 (1972)Cite this article

Abstract

THE importance of the participation of thymus-derived lymphocytes in both humoral antibody production1,2 and cell-mediated anti-allograft immunity3 has been clearly demonstrated. Evidence for the involvement of thymus-derived cells in the rejection of xenografts is, however, largely indirect. In mice, antilymphocyte serum (ALS) prolongs the survival of xeno-grafted skin4 and promotes the growth of tumour xenograft5. This can be taken to imply that thymus-derived cells are involved in the rejection process because ALS is known to deplete preferentially the thymus-dependent areas of lymphoid tissue6. Raff7 has also shown that in ALS treated mice the percentage of theta (θ) positive cells in lymphoid organs is decreased.

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Authors and Affiliations

  1. National Institute for Medical Research, London, NW7

    P. C. L. BEVERLEY & ELIZABETH SIMPSON

  2. Clinical Research Centre, Northwick Park, Middlesex

    P. C. L. BEVERLEY & ELIZABETH SIMPSON

Authors
  1. P. C. L. BEVERLEY
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  2. ELIZABETH SIMPSON
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BEVERLEY, P., SIMPSON, E. Cytotoxic Activity in vitro of Thymus-derived Lymphocytes Sensitized to Xenograft Antigens. Nature New Biology 237, 17–18 (1972). https://doi.org/10.1038/newbio237017a0

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