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Growth Response to Hormones by a New Rat Ovary Cell Line

Nature New Biology volume 236, pages 180–181 (1972)Cite this article

Abstract

SEVERAL endocrine cell lines established in recent years show a functional response to hormones in vitro1 but, except for one mammary cell line2, none of them exhibits the normal hormone requirement for growth in vivo. We have now isolated a rat ovarian cell line whose growth in vitro is markedly stimulated by bovine luteinizing hormone (LH-NIH-B7), a pituitary gonadotrophin, and by dexamethasone, a synthetic glucocorticoid. This cell line provides the first permanent in vitro system for studying the growth stimulation of gonadal cells by hormones.

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References

  1. Sato, G., Augusti-Tocco, G., and Posner, M., in Rec. Prog. Hormone Res. (edit. by Astwood, E. B.), 26, 539 (Academic Press, New York, 1969).

    Google Scholar 

  2. Sato, G., Clark, J., Posner, M., Leffert, H., Paul, D., Morgan, M., and Colby, C., in Karolinska Symposia on Research Methods in Reproductive Endocrinology (edit. by Diczfalusy, E.), 3, 126 (Bogtrykkeriet Forum, Copenhagen, 1971).

    Google Scholar 

  3. Amatayakul, K., Ryan, R., Oozumi, T., and Albert, A., Endocrinology, 88, 872 (1971).

    Article  CAS  Google Scholar 

  4. Gay, V. L., and Midgley, A. R., jun., Endocrinology, 84, 1359 (1969).

    Article  CAS  Google Scholar 

  5. Lawton, I. E., and Smith, S. W., Amer. J. Physiol., 219, 1019 (1970).

    Article  CAS  Google Scholar 

  6. Greep, R. O., and Jones, I. C., in Rec. Prog. Hormone Res. (edit. by Pincus, G.), 5, 197 (Academic Press, New York, 1950).

    Google Scholar 

  7. Achilles, W. E., and Sturgis, S. A., Endocrinology, 49, 720 (1951).

    Article  CAS  Google Scholar 

  8. Ely, C. A., Cancer Res., 19, 37 (1959).

    CAS  PubMed  Google Scholar 

  9. Zondek, B., Scand. Arch. Physiol., 70, 153 (1934).

    Article  Google Scholar 

  10. Leavitt, W. W., Carlson, I. H., and Meyer, R. K., Endocrinology, 88, 16 (1971).

    Article  CAS  Google Scholar 

  11. Biskind, M. S., and Biskind, G. R., Proc. Soc. Exp. Biol. Med., 55, 176 (1944).

    Article  CAS  Google Scholar 

  12. Furth, J., and Sobel, H., J. Nat. Canc. Inst., 8, 7 (1947).

    CAS  Google Scholar 

  13. Deane, H. W., and Fawcett, D. W., J. Nat. Canc. Inst., 17, 541 (1956).

    CAS  Google Scholar 

  14. Cuatrecasas, P., Wilcheck, M., and Annnsen, C. B., Proc. US Nat. Acad. Sci., 61, 636 (1968).

    Article  CAS  Google Scholar 

  15. Gospodarowicz, D., Biochim. Biophys. Acta (in the press).

  16. Todaro, G. J., and Green, H., J. Cell Biol., 17, 299 (1963).

    Article  CAS  Google Scholar 

  17. Yamamoto, M., Diebel, N. D., and Bogdanove, E. M., Endocrinology, 87, 798 (1970).

    Article  CAS  Google Scholar 

  18. Ahren, K., Hamberger, L., and Rubinstein, L., in The Gonads (edit. by McKerns, K. W.), 327 (Appleton-Century-Crofts, New York, 1969).

    Google Scholar 

  19. Lunenfeld, B., and Eshkol, A., in Vitamins and Hormones, 25 (edit. by Harris, R. S., Wool, I. G., and Loraine, J. A.), 137 (Academic Press, New York, 1967).

    Google Scholar 

  20. Pollack, R. E., Green, H., and Todaro, G. J., Proc. US Nat. Acad. Sci., 60, 126 (1968).

    Article  CAS  Google Scholar 

  21. Friedkin, M., in Ann. Rev. Biochem. (edit. by Snell, E. E.), 32, 185 (Banta, 1963).

    Google Scholar 

  22. Silagi, S., and Bruce, S. A., Proc. US Nat. Acad. Sci., 66, 72 (1970).

    Article  CAS  Google Scholar 

  23. Schubert, D., and Jacob, F., Proc. US Nat. Acad. Sci., 67, 247 (1970).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biology, University of California,

    JEFFREY L. CLARK

  2. Department of Pediatrics, University of California,

    KENNETH L. JONES

  3. Salk Institute for Biological Studies,

    DENNIS GOSPODAROWICZ

  4. Department of Biology, University of California, La Jolla, California, 92037

    GORDON H. SATO

Authors
  1. JEFFREY L. CLARK
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  2. KENNETH L. JONES
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  3. DENNIS GOSPODAROWICZ
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  4. GORDON H. SATO
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CLARK, J., JONES, K., GOSPODAROWICZ, D. et al. Growth Response to Hormones by a New Rat Ovary Cell Line. Nature New Biology 236, 180–181 (1972). https://doi.org/10.1038/newbio236180a0

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