Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Rapid Cycling of Plasma Gonadotrophins in Normal Men as demonstrated by Frequent Sampling

Abstract

HUMAN serum gonadotrophins have been studied and the general monotony of circulating levels encountered in males has been stressed1-3. The question of a possible diurnal variation in gonadotrophin secretion in men has not been settled because of disagreement between authors, even after hourly sampling2, 4–6. The recent report of five to ten peaks of plasma luteinizing hormone (LH) per day in the standing bull during hourly observations7 and the demonstration of the short half-times of circulating human gonadotrophins8,9 have caused us to evaluate the minute-to-minute control of circulating gonadotrophins in men.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Naftolin, F., Espeland, D., Tremann, J. A., Dillard, E. A., and Paulsen, C. A., in Gonadotropins (edit. by Rosemberg, E.), 373 (Geron-X, Los Altos, California, 1968).

    Google Scholar 

  2. Franchimont, P., in Advances in Biosciences (edit. by Raspé, G.), 1, 19 (Pergamon Press, Oxford, 1968).

    Google Scholar 

  3. Swerdloff, R. S., and Odell, W. D., California Medicine, 109, 476 (1968).

    Google Scholar 

  4. Peterson, N. T., Midgley, A. R., and Jaffe, R. B., J. Clin. Endocrinol., 28, 1473 (1968).

    Article  CAS  Google Scholar 

  5. Faiman, C., and Ryan, R. J., Nature, 215, 857 (1967).

    Article  CAS  Google Scholar 

  6. Saxena, B. B., Demura, H., Gandy, H. M., and Peterson, R. E., J. Clin. Endocrinol., 28, 519 (1968).

    Article  CAS  Google Scholar 

  7. Katongole, C. B., Naftolin, F., and Short, R. B., J. Endocrinol., 50, 457 (1971).

    Article  CAS  Google Scholar 

  8. Yen, S. S. C., Llerena, O., Little, B., and Pearson, O. H., J. Clin. Endocrinol., 28, 1763 (1968).

    Article  CAS  Google Scholar 

  9. Yen, S. S. C., Llerena, L. A., Pearson, O. H., and Littell, A. S., J. Clin. Endocrinol., 30, 325 (1970).

    Article  CAS  Google Scholar 

  10. Schally, A. V., Arimura, A., Baba, Y., Nair, R. M. G., Matsuo, H., Redding, T. W., Debeljuk, L., and White, W. F., Biochem. Biophys. Res. Commun., 43, 393 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

NAFTOLIN, F., YEN, S. & TSAI, C. Rapid Cycling of Plasma Gonadotrophins in Normal Men as demonstrated by Frequent Sampling. Nature New Biology 236, 92–93 (1972). https://doi.org/10.1038/newbio236092a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio236092a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing