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Response of Mouse T and B Lymphocytes to Sheep Erythrocytes

Nature New Biology volume 235, pages 115–118 (1972)Cite this article

Abstract

THE primary immune response of mice to sheep red blood cells (SRBC) involves two types of lymphocytes: the antibody-forming cell series, whose precursors are found in bone marrow (B cells), and cooperating or “helper” cells of uncertain function whose precursors are found in the thymus (T cells)1. Within 24 h of an intravenous injection of SRBC, an increase of haemolytic antibody plaque-forming cells (p.f.c.) occurs in the spleen, reaching a peak 5 days later. Part, but not all, of this increase is due to division among the B cells2. T cells in the spleen also undergo a wave of mitosis, detectable from the second to the fifth day3.

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Authors and Affiliations

  1. Department of Immunology, Middlesex Hospital Medical School, London, W1

    J. H. L. PLAYFAIR

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  1. J. H. L. PLAYFAIR
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PLAYFAIR, J. Response of Mouse T and B Lymphocytes to Sheep Erythrocytes. Nature New Biology 235, 115–118 (1972). https://doi.org/10.1038/newbio235115a0

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