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Bacteriophage and the Toxigenicity of Clostridium botulinum Type D

Abstract

THE data of Inoue and Iida1,2 strongly suggest that bacteriophage is involved in the toxigenicity of Clostridium botulinum types C and D. They were able to recover toxigenic isolates from nontoxigenic cultures incubated in broth containing filtrates of the toxigenic strains (Stockholm strain of type C and strain 1873 of type D). Lysis was observed in the cultures, but plaques were not demonstrated on solid medium. The change from hontoxigenicity to toxigenicity in C. botulinum type C strain 468C has been shown3 to require the active and continued participation of a specific bacteriophage designated CEβ.

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References

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EKLUND, M., POYSKY, F. & REED, S. Bacteriophage and the Toxigenicity of Clostridium botulinum Type D. Nature New Biology 235, 16–17 (1972). https://doi.org/10.1038/newbio235016a0

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