Abstract
THE data of Inoue and Iida1,2 strongly suggest that bacteriophage is involved in the toxigenicity of Clostridium botulinum types C and D. They were able to recover toxigenic isolates from nontoxigenic cultures incubated in broth containing filtrates of the toxigenic strains (Stockholm strain of type C and strain 1873 of type D). Lysis was observed in the cultures, but plaques were not demonstrated on solid medium. The change from hontoxigenicity to toxigenicity in C. botulinum type C strain 468C has been shown3 to require the active and continued participation of a specific bacteriophage designated CEβ.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Universal and specific quantitative detection of botulinum neurotoxin genes
BMC Microbiology Open Access 20 October 2010
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Inoue, K., and Iida, H., Jap. J. Microbiol., 14, 87 (1970).
Inoue, K., and Iida, H., Proc. Interagency Botulism Res. Coordinating Committee and UJNR Panels on Toxic Microorganisms (1970).
Eklund, M. W., Poysky, F. T., Reed, S. M., and Smith, C. A., Science, 172, 480 (1971).
Eklund, M. W., Poysky, F. T., and Wieler, D. I., Appl. Microbiol., 15, 1316 (1967).
Adams, M. H., Bacteriophage (Interscience, New York, 1959).
Segner, W. P., Schmidt, C. F., and Boltz, J. K., Report No. COO-1183-32 (US Atomic Energy Commission, Washington DC, 1970).
Eklund, M. W., Poysky, F. T., and Boatman, E. S., J. Virol, 3, 270 (1969).
Inoue, K., and Iida, H., J. Virol., 2, 537 (1968).
Bott, K., and Strauss, B., Virology, 25, 202 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
EKLUND, M., POYSKY, F. & REED, S. Bacteriophage and the Toxigenicity of Clostridium botulinum Type D. Nature New Biology 235, 16–17 (1972). https://doi.org/10.1038/newbio235016a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio235016a0
This article is cited by
-
Clostridium perfringens bacteriophages ΦCP39O and ΦCP26F: genomic organization and proteomic analysis of the virions
Archives of Virology (2011)
-
Universal and specific quantitative detection of botulinum neurotoxin genes
BMC Microbiology (2010)
-
Organization of the botulinum neurotoxin C1 gene and its associated non-toxic protein genes in Clostridium botulinum C468
Molecular and General Genetics MGG (1994)