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New Plasma Autoantigen and its Role in Autoimmune Disease of New Zealand Black Mice

Nature New Biology volume 234, pages 279–281 (1971)Cite this article

Abstract

THE New Zealand Black (NZB) strain of mice is an important experimental model for the study of autoimmune diseases1. These mice are immunologically hyper-responsive to a number of antigens2,3 and spontaneously initiate autoantibody responses to various autologous tissue antigens, including DNA and an erythrocyte antigen1,3,4. The significance of anti-DNA5 and anti-murine leukaemia virus (MuLV)6 responses relative to the pathogenesis of the glomerulonephritis observed in this strain has been the subject of rather concerted inquiry, and a proposed immune complex pathogenetic process has been substantiated5–7. The anti-erythrocyte autoantibody response seems to be immunochemically and pathogenetically distinct4,6.

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References

  1. Howie, J. B., and Helyer, B. J., in Advances in Immunology (edit. by Dixon, jun., F. J., and Kunkel, Henry G.), 9, 215 (Academic Press, New York, 1968).

    Google Scholar 

  2. Hahn, B. H., Stevens, M. B., Remington, M., and Shulman, L. E., J. Lab. Clin. Med., 77, 558 (1971).

    CAS  PubMed  Google Scholar 

  3. Lambert, P. H., and Dixon, F. J., Clin. Exp. Immunol., 6, 829 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Long, G., Holmes, M. C., and Burnet, F. M., Austral. J. Exp. Biol., 41, 315 (1963).

    Article  CAS  Google Scholar 

  5. Lambert, P. H., and Dixon, F. J., J. Exp. Med., 127, 507 (1968).

    Article  CAS  Google Scholar 

  6. Mellors, R. C., Aoki, T., and Huebner, R. J., J. Exp. Med., 129, 1045 (1969).

    Article  CAS  Google Scholar 

  7. Tonietti, G., Oldstone, M. B. A., and Dixon, F. J., J. Exp. Med., 132, 71 (1970).

    Article  Google Scholar 

  8. Edgington, T. S., Glassock, R. J., and Dixon, F. J., Science, 155, 1432 (1967).

    Article  CAS  Google Scholar 

  9. Stockert, E., Old, L. J., and Boyse, E. A., J. Exp. Med., 133, 1334 (1971).

    Article  CAS  Google Scholar 

  10. Weiner, W., Brit. J. Haematology, 3, 276 (1957).

    Article  CAS  Google Scholar 

  11. Edgington, T. S., J. Immunol., 106, 673 (1971).

    CAS  PubMed  Google Scholar 

  12. Linder, E. J., and Edgington, T. S., Vox Sang., 21 (in the press).

  13. Snell, G. D., and Stimpfling, J. H., in Biology of the Laboratory Mouse (edit, by Green, E. L.), second ed., 473 (McGraw Hill, New York, 1966).

    Google Scholar 

  14. Aoki, T., Boyse, E. A., Old, L. J., de Harven, E., Hämmerling, U., and Wood, H. A., Proc. US Nat. Acad. Sci., 65, 569 (1970).

    Article  CAS  Google Scholar 

  15. Aoki, T., Boyse, E. A., and Old, L. J., J. Nat. Cancer Inst., 41, 97 (1968).

    CAS  PubMed  Google Scholar 

  16. Lerner, R. A., Oldstone, M. B. A., and Cooper, N. R., Proc. US Nat. Acad. Sci., 68 (in the press).

  17. Wigzell, H., J. Immunol., 97, 608 (1966).

    CAS  PubMed  Google Scholar 

  18. Diener, E., and Feldman, M., J. Exp. Med., 132, 31 (1970).

    Article  CAS  Google Scholar 

  19. Uhr, J. W., and Möller, G., Adv. Immunol., 8, 81 (1968).

    Article  CAS  Google Scholar 

  20. Levy, J. A., and Pincus, T., Science, 170, 326 (1970).

    Article  CAS  Google Scholar 

  21. Mellors, R. C., Shirai, T., Aoki, T., Huebner, R. J., and Krawczynski, K., J. Exp. Med., 133, 113 (1971).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California, 92037

    E. J. LINDER & T. S. EDGINGTON

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  1. E. J. LINDER
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  2. T. S. EDGINGTON
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LINDER, E., EDGINGTON, T. New Plasma Autoantigen and its Role in Autoimmune Disease of New Zealand Black Mice. Nature New Biology 234, 279–281 (1971). https://doi.org/10.1038/newbio234279a0

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